One way to compose a dream team, is by looking for new microbial talents, under very specific conditions. This exemplifies the research of the Biodiscovery...Read More
ABOUT THE biodiscovery PLATFORM
The high-throughput cultivation and Biodiscovery Platform allows for isolation and investigation of yet unknown microorganisms. Subsequently, these can be used as building blocks for synthetic communities. The platform is geared towards strictly anaerobic microorganisms, but is universally applicable.
Wageningen University & Research
high-throughput cultivation, single-cell based, microfluidic cell sorting, microbioreactor unit, high throughput sample processing unit, anaerobic cultivation
FREQUENTLY ASKED QUESTIONS
The Biodiscovery Platform is a single cell-based high-throughput cultivation and biodiscovery platform specifically adapted to the recovery of yet-uncultured strictly anaerobic microorganisms. In brief, it allows the design, construction and testing of defined synthetic or minimal microbial communities.
Defined synthetic or minimal microbial communities represent more complex natural microbial communities. In the future, they could provide important contributions to food safety and production, human and animal health, bioresource utilization and sustainable production of biobased chemicals.
The ability to assemble synthetic communities is often based on genome-predicted functionalities of individual microbial species. It depends on the availability of individual microorganisms either as pure cultures or – in case of strains not previously obtained in culture – physically isolated cells.
The platform is specifically tuned to the discovery, characterization and utilization of strict anaerobes. It can, however, also be used for aerobic, microaerophilic and facultatively anaerobic microorganisms.
The platform comprises a central sample processing platform that provides high-throughput capacity for largely automated sample processing and storage for downstream biomolecular and metabolome analyses. For additional info, read the technical details below.
Other platform benefits
Microfluidic cell sorting and microbioreactors
Integration with other platforms
Most promising synthetic microbial communities can then be further studied in the larger and more advanced reactors of the Parallel Cultivation and/or Modular Bioreactor platforms. These platforms allow for more detailed experiments to investigate intercellular interactions and to understand as well as control spatiotemporal coordination, robustness, and stability of the novel synthetic consortia.